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Haematology

Containing dedicated Learning Zones, guidelines, trials and news for related conditions in Haematology.

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Haematology is the branch of medicine that deals with disorders or abnormalities in the blood and connected areas such as blood cells, haemoglobin and blood vessels. Haematology also covers bone marrow and spleen, which are the blood producing organs.

Featured Learning Zones

Learning Zone Homepage

Fibrinogen Deficiency in Bleeding Learning Zone

Fibrinogen is an essential coagulation factor in the blood clotting cascade. The importance for fibrinogen in normal haemostasis is highlighted in patients of inherited fibrinogen deficiencies who display coagulopathies such as excessive bleeding and thrombolytic events.

Learning Zone Homepage

Oral Anticoagulation Reversal Learning Zone

This educational resource is designed to help healthcare professionals diagnose, manage and treat bleeding in patients taking anticoagulants.

Cancer-Associated Thrombosis Learning Zone

Cancer‐associated thrombosis (CAT) is a frequent, potentially life‐threatening event that complicates cancer management. New treatments, including DOACs, are now recommended for CAT

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Haematology focuses on the study, diagnosis, treatment, and prevention of diseases including coagulation and haemorrhagic disorders such as fibrinogen deficiency, haematological and bone marrow cancers such as leukaemia and lymphoma, and anaemia.

Diseases in this section

Coagulation and Haemorrhagic Disorders

Containing relevant Learning Zones, guidelines, trials and news.

Haematological and Bone Marrow Cancers

Containing relevant Learning Zones, guidelines, trials and news.

HIV / AIDS

Containing relevant Learning Zones, guidelines, trials and news.

Venous thromboembolism

Containing relevant Learning Zones, guidelines, trials and news.

Related news and insights

Drug news

New Data for Genentech’s Hemlibra reinforce safety profile in people with hemophilia A.

Genentech, a member of the Roche Group announced results from the final analysis of the Phase IIIb STASEY study, which confirm the favorable safety profile of Hemlibra (emicizumab-kxwh), consistent with the Phase III HAVEN clinical program. In the analysis, no new safety signals were identified with longer-term Hemlibra treatment in adults and adolescents with hemophilia A with inhibitors to factor VIII, the clotting protein that is missing or defective in people with hemophilia A. The data were presented at the virtual International Society on Thrombosis and Haemostasis (ISTH) 2021 Congress, July 17-21.

1 mins

Drug news

Four-year Biktarvy data presented at IAS 2021

Gilead Sciences, Inc. announced a pooled analysis of a 48-week open-label extension of two Phase III studies (Study 1489 and Study 1490) shows 99% of participants who initiated treatment with Biktarvy (bictegravir 50 mg/emtricitabine 200 mg/tenofovir alafenamide 25 mg tablets, B/F/TAF) maintained an undetectable viral load (HIV-1 RNA <50 copies ml) through four years of follow-up (week 192, n="476/480," missing="excluded)." in the 48-week open-label extension, there were zero cases of treatment-emergent resistance to any components of biktarvy in participants treated with biktarvy. these findings, along with long-term data from phase iii studies in virologically suppressed black americans and virologically suppressed people living with hiv aged 65 and older, demonstrated biktarvy sustains efficacy with a high barrier to resistance across a range of people living with hiv, inclusive of their treatment history, gender, race or age. these data were presented at the 11th international aids society (ias) conference on hiv science.></50>

2 min

Drug news

New phase III data support the sustained, long-acting efficacy of lenacapavir

Gilead Sciences, Inc. announced new results from the ongoing Phase II/III CAPELLA trial evaluating lenacapavir, the company’s investigational, long-acting HIV-1 capsid inhibitor, in heavily treatment-experienced people living with multi-drug resistant HIV.

3 min

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Related Drugs

ALPROLIX 500 IU powder and solvent for solution for injection

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Thalidomide 50mg hard capsules

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OPDIVO 10 mg/mL concentrate for solution for infusion (Northern Ireland)

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Arsenic trioxide Mylan 1 mg/ml concentrate for solution for infusion

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Arsenic Trioxide 1 mg/ml concentrate for solution for infusion

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Anagrelide 0.5 mg Hard Capsules

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Sytron

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Pregaday 322mg / 0.35mg film-coated Tablets

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Menadiol Diphosphate 10mg Tablets

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Ironorm Drops

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Galfer FA Capsules

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Galfer Syrup

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Related Journals

Journal

Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report

2 mins

Journal

Safety and immunogenicity of two heterologous HIV vaccine regimens in healthy, HIV-uninfected adults (TRAVERSE): a randomised, parallel-group, placebo-controlled, double-blind, phase 1/2a study

2 mins

Journal

Distinct viral reservoirs in individuals with spontaneous control of HIV-1

1 mins

Journal

Recent Advances in the Development of Integrase Inhibitors for HIV Treatment

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Journal

Long-Acting Cabotegravir and Rilpivirine for Maintenance of HIV-1 Suppression

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Journal

Fostemsavir in Adults with Multidrug-Resistant HIV-1 Infection

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Journal

Advances toward Curing HIV-1 Infection in Tissue Reservoirs

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Journal

Two-drug regimens with dolutegravir plus rilpivirine or lamivudine in HIV-1 treatment-naïve, virologically-suppressed patients: Latest evidence from the literature on their efficacy and safety

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Journal

Long-term data on the efficacy and tolerability of lamivudine plus dolutegravir as a switch strategy in a multi-centre cohort of HIV-1-infected, virologically suppressed patients

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Journal

Dolutegravir plus lamivudine for the treatment of HIV-1 infection

1 mins

Related Guidelines

Guideline

BHIVA guidelines for the management of HIV in pregnancy and postpartum 2018 (2020 third interim update)

The overall purpose of these guidelines is to provide guidance on best clinical practice in the treatment and management of women living with HIV in the UK during pregnancy and postpartum, and their infants.

1 mins

Guideline

British HIV Association guidelines on the management of opportunistic infection in people living with HIV: The clinical management of Candidiasis 2019

The aim of the opportunistic infection guidelines is to help physicians investigate and manage people living with HIV with, or suspected of having, an opportunistic infection. They are primarily intended to guide practice in the UK and related healthcare systems.

1 min

Guideline

British HIV Association guidelines on the management of opportunistic infection in people living with HIV: The clinical management of gastrointestinal opportunistic infections 2020

Gastrointestinal (GI) symptoms occur frequently in people living with HIV. Dysphagia and diarrhoea may be caused by a wide variety of infections.

1 min

See all guidelines

Related Clinical Trials

Clinical trial

Study to Evaluate the Safety and Efficacy of Lenacapavir in Combination With Other Antiretroviral Agents in People Living With HIV (CALIBRATE)

1 mins

Clinical trial

Study to Evaluate the Safety and Efficacy of Lenacapavir in Combination With an Optimized Background Regimen in Heavily Treatment Experienced Participants Living With HIV-1 Infection With Multidrug Resistance (CAPELLA)

1 mins

Clinical trial

Attachment Inhibitor Comparison in Heavily Treatment Experienced Patients

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Clinical trial

Safety and Efficacy of Dolutegravir/Lamivudine (DTG/3TC) in Therapy-naive Human Immunodeficiency Virus-1 (HIV-1) Infected Adolescents

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Clinical trial

Switch Study to Evaluate Dolutegravir Plus Lamivudine in Virologically Suppressed Human Immunodeficiency Virus Type 1 Positive Adults (TANGO)

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Clinical trial

A Study to Investigate Different Doses of BAY1213790 to Prevent Blood Clots in Patients Undergoing Elective Total Knee Replacement Surgery (FOXTROT)

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$Dose Escalation Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of ASP2215 in Patients With Relapsed or Refractory Acute Myeloid Leukemia$

Clinical trial

Dose Escalation Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of ASP2215 in Patients With Relapsed or Refractory Acute Myeloid Leukemia

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$A Phase III Study Of Gemcitabine, Dexamethasone, And Cisplatin Compared To Dexamethasone, Cytarabine, And Cisplatin Plus/Minus Rituximab [(R)-GDP vs (R)-DHAP] As Salvage Chemotherapy For Patients With Relapsed Or Refractory Aggressive Histology Non-Hodgki$

Clinical trial

A Phase III Study Of Gemcitabine, Dexamethasone, And Cisplatin Compared To Dexamethasone, Cytarabine, And Cisplatin Plus/Minus Rituximab [(R)-GDP vs (R)-DHAP] As Salvage Chemotherapy For Patients With Relapsed Or Refractory Aggressive Histology Non-Hodgki

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Clinical trial

Study of Acalabrutinib Versus Chlorambucil Plus Rituximab in Adult Subjects With Previously Untreated Chronic Lymphocytic Leukemia

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Clinical trial

Quizartinib With Standard of Care Chemotherapy and as Continuation Therapy in Patients With Newly Diagnosed FLT3-ITD (+) Acute Myeloid Leukemia (AML) (QuANTUM-First)

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Clinical trial

Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation

3 mins

$Study of pomalidomide and low dose dexamethasone with or without pembrolizumab (MK-3475) in refractory or relapsed and refractory multiple myeloma (rrMM) (MK-3475-183/KEYNOTE-183)$

Clinical trial

Study of pomalidomide and low dose dexamethasone with or without pembrolizumab (MK-3475) in refractory or relapsed and refractory multiple myeloma (rrMM) (MK-3475-183/KEYNOTE-183)

2 mins