Recently added: Latest insights in oral anticoagulation and its reversal in our new Key Learnings section with COVID-19 details, and the latest publication digest: Managing bleeds related to oral factor Xa inhibitors with andexanet alfa or replacement agents
Symposia highlights from the 39th International Symposium on Intensive Care And Emergency Medicine 2019.
The aim of this Learning Zone is to give an overview of blood coagulation, anticoagulation, bleeding risk and the various methods for the management and treatment of bleeding in patients taking anticoagulants. Details of blood coagulation factors II, VII, IX and more; the coagulation cascade; haemorrhagic risk assessment, using the international normalised ratio; the factor Xa inhibitors rivaroxaban, edoxaban or apixaban; the factor IIa (thrombin) inhibitor dabigatran; the risks of warfarin treatment; current national and international guidelines; the use of fresh frozen plasma to reverse vitamin K antagonist (VKA) anticoagulation; plasma and rVIIA; and details of the anticoagulation reversal agents idarucizumab, andexanet alpha and ciraparantag are all included in this section.
The Oral Anticoagulants section goes on to provide information on the options available for oral anticoagulation, such as factor Xa and IIa inhibitors. Details of the effects that VKAs can have on patients with atrial fibrillation, heart failure, valvular heart disease, venous thromboembolism and transient ischaemic attacks; the use of paracetamol and an adjuvant therapy; how the CYP2C9 and VKORC1 genes affect blood coagulation; and details of non-vitamin K oral anticoagulants, such as factor Xa inhibitors, rivaroxaban, apixaban, edoxaban, and the factor IIa inhibitor dabigatran are all included in this section.
COVID-19 and anticoagulation
Emerging evidence is revealing that severe coronavirus disease 2019 (COVID-19) is associated with coagulation abnormalities and an increased risk of venous thromboembolism. Could patients with severe cases of COVID-19 benefit from anticoagulant therapy?
Watch video presentations from Donat Spahn - 'The elements of trauma induced coagulopathy' and 'Key recommendations in the reversal of antithrombotic agents.'
Discover how blood coagulates, how drugs work to reverse coagulation, what diagnostic tests are used to assess bleeding risk and how to treat anticoagulant-associated bleeding.
With oral vitamin K antagonists and non-vitamin K oral anticoagulants being covered, you'll be able to understand the merits and drawbacks of individual treatments in detail.
Recent publications will be reviewed and distilled into key learning points for your convenience, sorted by year of publication.