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Cystic Fibrosis

Read time: 5 mins
Last updated: 30th Mar 2020

Cystic Fibrosis is a chronic, progressive, and frequently fatal genetic disease primarily affecting the respiratory and digestive systems in children and young adults. It is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR). When the CFTR ceases to function, it affects the secretion of digestive fluids, mucus and sweat

Cystic fibrosis is a multi-system disease affecting organs and tissues where CFTR is expressed. The most common clinical features are exocrine pancreatic insufficiency, mucus discharge from the lungs, bronchiectasis with chronic airway infection, leading to respiratory failure and premature death. Mucus also clogs the pancreas, which stops enzymes reaching food in the gut and helping with digestion. It is also related to other conditions, including diabetes, osteoporosis, infertility in males, and liver problems.

 

Cystic Fibrosis is a chronic, progressive, and frequently fatal genetic disease primarily affecting the respiratory and digestive systems in children and young adults. It is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR). When the CFTR ceases to function, it affects the secretion of digestive fluids, mucus and sweat

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