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CDK4/6 inhibitors in breast cancer

Publication digest

Read time: 30 mins
Last updated:12th Aug 2022
Published:12th Aug 2022

View our publication digests to learn key findings on the use of CDK4/6 inhibitors for treatment of HR+, HER2−, node-positive, high-risk, or early breast cancer.

  • Review data showing improved outcomes from CDK4/6 inhibitor abemaciclib plus endocrine therapy
  • Learn the long-term benefits of adjuvant abemaciclib combined with endocrine therapy
  • Consider the safety and tolerability profile of this combination therapy for breast cancer

Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study

Harbeck et al. Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study. Ann Oncol. 2021;32(12):1571‒1581.

Adjuvant abemaciclib combined with endocrine therapy (ET) previously demonstrated clinically meaningful improvement in invasive disease-free survival (IDFS) and distant relapse-free survival (DRFS) in hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER-), node-positive, high-risk early breast cancer (EBC)1. However, follow-up from this study was limited to 24 months, necessitating further investigation. An additional 3-year follow up analysis was therefore performed, which found that adjuvant abemaciclib combined with ET improved IDFS and DRFS, and that the benefit observed in the initial monarchE study extended beyond the 2-year treatment period with a similar safety and tolerability profile2.

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CDK4/6 inhibitors in combination with endocrine therapy as potential therapies for treating high-risk early breast cancer patients

Does addition of abemaciclib to endocrine therapy (ET) as an adjuvant treatment of HR+, HER2−, node-positive, high-risk, early breast cancer patients provide additional benefits versus treatment with ET alone?

Johnston S, Harbeck N, Hegg R, Toi M, Martin M, Shao ZM, et al. Abemaciclib combined with endocrine therapy for the adjuvant treatment of HR+, HER2-, node-positive, high-risk, early breast cancer (monarchE). J Clin Oncol. 2020:JCO2002514.

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References

  1. Johnston SRD, Harbeck N, Hegg R, Toi M, Martin M, Shao ZM, et al. Abemaciclib Combined With Endocrine Therapy for the Adjuvant Treatment of HR+, HER2-, Node-Positive, High-Risk, Early Breast Cancer (monarchE). J Clin Oncol. 2020;38(34):3987-3998.
  2. Harbeck N, Rastogi P, Martin M, Tolaney SM, Shao ZM, Fasching PA, et al. Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study. Ann Oncol. 2021;32(12):1571-1581.
  3. Cardoso F, Spence D, Mertz S, Corneliussen-James D, Sabelko K, Gralow J, et al. Global analysis of advanced/metastatic breast cancer: Decade report (2005-2015). Breast. 2018;39:131-138.
  4. Howlader N, Altekruse SF, Li CI, Chen VW, Clarke CA, Ries LA, et al. US incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status. J Natl Cancer Inst. 2014;106(5).
  5. Lerebours F, Pulido M, Fourme E, Debled M, Becette V, Bonnefoi H, et al. Predictive factors of 5-year relapse-free survival in HR+/HER2- breast cancer patients treated with neoadjuvant endocrine therapy: pooled analysis of two phase 2 trials. Br J Cancer. 2020;122(6):759-765.
  6. Mamounas EP, Tang G, Paik S, Baehner FL, Liu Q, Jeong JH, et al. 21-Gene Recurrence Score for prognosis and prediction of taxane benefit after adjuvant chemotherapy plus endocrine therapy: results from NSABP B-28/NRG Oncology. Breast Cancer Res Treat. 2018;168(1):69-77.
  7. Shah M, Nunes MR, Stearns V. CDK4/6 Inhibitors: Game Changers in the Management of Hormone Receptor-Positive Advanced Breast Cancer? Oncology (Williston Park). 2018;32(5):216-222.
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