CDK4/6 inhibitors in mBC
Breast cancer accounts for almost one-quarter of all cancer cases in women worldwide. In 2018 alone, there were an estimated 2.1 million new cases1, with over 520,000 of these reported in European countries2.
Given the heterogeneity of breast cancer, personalisation of treatment is critical.
Metastatic breast cancer remains largely incurable. However, with some patients achieving long-term relapse-free survival, discussion is now ongoing as to whether a subset of patients may be curable with a more aggressive multidisciplinary team approach and curable intent29.
However, in the absence of a cure, the goal of treatment must be to extend life and delay disease progression while ensuring that patients continue to have the best quality of life for as long as possible3.
There are three cyclin-dependent kinase 4/6 (CDK4/6) inhibitors which are EMA and FDA approved for the treatment of HR+/HER2- metastatic breast cancer; abemaciclib, palbociclib and ribociclib58–63.
The CDK4/6 inhibitors palbociclib, ribociclib and abemaciclib have all been approved for the treatment of HR+/HER2- metastatic breast cancer by the FDA and EMA58–60,76–78.
In this 4–minute video, Dr Gregory Vidal from the West Cancer Centre and Research Institute (University of Tennessee, USA) shares his view on the latest exciting developments related to the landmark clinical trials for CDK4/6 inhibitors in patients with HR+/HER2- metastatic breast cancer.
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