Food for Thought Podcast Series
Expert opinion on food allergy diagnosis, treatments, and guidelines
In this podcast series, Professor Alexandra Santos leads discussion on food allergy diagnostics and therapies with international experts, including Dr Sharon Chinthrajah, Professor Hugh Sampson, Dr Tina Sindher, Dr Kari Nadeau, Professor Gideon Lack, Professor Douglas Mack, and Dr Aikaterini Anagnostou.
This podcast is intended for Healthcare Professionals only.
Episode 1: Overcoming challenges of integrating oral immunotherapy for food allergy into clinical practice
In Episode 1, Professor Alexandra Santos is joined by Dr Sharon Chinthrajah and Dr Tina Sindher for discussion on the benefits and risks of oral immunotherapy (OIT), and guideline recommendations for OIT in the food allergy setting. Click play to listen to Episode 1 now.
Episode 2: Epitope testing and the basophil activation test (BAT): going beyond food challenge testing
Join Professor Alexandra Santos, Dr Sharon Chinthrajah and Professor Hugh Sampson as they discuss food allergy diagnosis and some of the limitations behind current diagnostic techniques. In addition, they explore features of the ideal diagnostic test and tests that are currently under development. Click play to listen to Episode 2 now.
Episode 3: Strategies for prevention in food allergy
Join Professor Sharon Chinthrajah, with Professor Kari Nadeau and Professor Gideon Lack as they discuss the latest prevention strategies for food allergy, particularly in infants, and the rationale behind skin barrier interventions.
Meet the experts
Professor Alexandra Santos
Dr Alexandra Santos is Associate Professor in Paediatric Allergy at King’s College London, and Honorary Consultant in Paediatric Allergy at the Evelina London Children’s Hospital. The Santos Lab aims to improve the accuracy and safety of food allergy diagnosis and our understanding of the mechanisms of food allergy and oral tolerance in IgE-sensitised children. Alexandra is the Chair of the Board of the Food Allergy Interest Group of European Academy of Allergy and Clinical Immunology (EAACI) and of the upcoming EAACI Food Allergy Guidelines.
Disclosures: Consultancy and/or speaker fees from Thermo Scientific, Nutricia, Infomed, Novartis, Allergy Therapeutics, Buhlmann, as well as research support from Buhlmann and Thermo Fisher Scientific through a collaboration agreement with King's College London.
Dr Sharon Chinthrajah
Dr Sharon Chinthrajah is Director of the Clinical Translational Research Unit of the Sean N Parker Centre for Allergy and Asthma Research (Stanford University), where she leads novel and impactful Phase 1-3 studies in food allergy, asthma, allergic rhinitis, and atopic dermatitis.
Disclosures: Dr Chinthrajah has grants from NIAID, CoFAR, Aimmune, DBV Technologies, Astellas, Regeneron, Stanford Maternal and Child Health Research Institute (MCHRI), and FARE. She is an Advisory Board Member at Alladapt Therapeutics, Novartis, Genentech, Sanofi, Allergenis, and Intrommune Therapeutics.
Dr Tina Sindher
Dr Sindher joined the Sean N. Parker Center for Allergy and Asthma Research at Stanford University in January 2017, and is Director of the Clinical Translational Research Unit. Dr Sindher conducts clinical research trials at the Sean N. Parker Center and the Oral Immunotherapy Clinic at Lucille Packard Children’s Hospital (LPCH), which is focused on the care of paediatric allergy and immunology patients. Her interests are in food allergy and eosinophilic esophagitis research involving strategies for prevention, diagnostics, and novel therapeutics.
Disclosures: Grants from NIH, Regeneron, DBV Technologies, Aimmune, Novartis, CoFAR, and FARE. She is an Advisory member at Genentech and DBV Technologies.
Professor Hugh Sampson
Professor Hugh A. Sampson is the Kurt Hirschhorn Professor of Pediatrics at the Icahn School of Medicine in New York and has over 40 years’ experience in translational research focusing on food allergic disorders and basic immunologic mechanisms responsible for these disorders. His research has been funded continuously by grants from the NIH, including the Principal Investigator for the Consortium for Food Allergy Research. He has authored/co-authored over 550 original articles and 90 book chapters, and co-edited 5 books, primarily on clinical and immunopathogenic aspects of food allergic disorders, and chaired working groups that produced standardised criteria for diagnosing anaphylaxis and conducting double-blind placebo-controlled oral food challenges (Practall Guidelines). Professor Sampson was elected to membership in the National Academy of Medicine of the National Academies in 2003 for his research accomplishments. He is the past president of the American Academy of Asthma, Allergy & Immunology, past Chairman of the Section on Allergy & Immunology of the American Academy of Pediatrics, past Board member of the World Allergy Organization, and has served on the Editorial Boards of five allergy journals. Professor Sampson has trained over 40 post-doctoral allergy/immunology fellows, many of whom are now leaders in the field of food allergy.
Disclosures: Professor Sampson reports consultancy fees from N-Fold, LLC, DBV Technologies, and Siolta Therapeutics; grant funding from the National Institutes of Health (NIH)/National Institute of Allergy and Infectious Diseases (NIAID); and royalties from Elsevier.
Professor Kari Nadeau
Professor Kari Nadeau is the Naddisy Foundation Professor of Medicine and Pediatrics and, Director of the Sean N. Parker Center for Allergy and Asthma Research at Stanford University. She is Section Chief in Asthma and Allergy in Pulmonary and Critical Care at Stanford and a pediatrician and practices Allergy, Asthma, Immunology in children and adults. For more than 30 years, she has devoted herself to understanding how environmental and genetic factors affect the risk of developing allergies and asthma, and the molecular mechanisms underlying the asthma and its severity. Professor Nadeau has taught medical students, graduate students, undergraduate students and post docs for over 16 years at Stanford. Her accomplishments to date include over 240 peer-reviewed publications.
Disclosures: Professor Nadeau reports grants from National Institute of Allergy and Infectious Diseases (NIAID), National Heart, Lung, and Blood Institute (NHLBI), National Institute of Environmental Health Sciences (NIEHS), and Food Allergy Research & Education (FARE); Stock options from IgGenix, Seed Health, ClostraBio, Cour, Alladapt, Clostrabio, and ImmuneID; Director of the World Allergy Organization Center of Excellence for Stanford; Advisor at Cour Pharma; Consultant for Excellergy, Red tree ventures, Before Brands, Alladapt, Cour, Latitude, Regeneron, and IgGenix; Co-founder of Before Brands, Alladapt, Latitude, and IgGenix; National Scientific Committee member at Immune Tolerance Network (ITN), and National Institutes of Health (NIH) clinical research centres; patents include, “Mixed allergen composition and methods for using the same,” “Granulocyte-based methods for detecting and monitoring immune system disorders,” and “Methods and Assays for Detecting and Quantifying Pure Subpopulations of White Blood Cells in Immune System Disorders”.
Professor Gideon Lack
Professor Gideon Lack is Professor of Paediatric Allergy at King’s College London and Head of the Children’s Allergy Clinical Academic Group at King’s Health Partners Institute of Women and Children’s Health at Evelina London, Guy’s & St. Thomas’ NHS Foundation Trust. He was co-author on the LEAP (Learning Early About Peanut allergy) study that showed that early consumption of peanuts in atopic infants reduces the development of peanut allergy by >80%, which translated to changes to health policy in the USA and Australia. His research focuses on the prevalence of food allergies in children and the relationship between food allergies, eczema, and asthma. He works on novel immune-modulatory treatments for food allergies and on developing new strategies to prevent the development of allergies and asthma in children and adults.
Disclosures: Professor Lack is a stock shareholder in DBV Technologies, Mission Mighty Me, and serves as a Member of Scientific Advisory Board at DBV Technologies S.A. He received honoraria from EPG Health for participating in a company-sponsored speaker’s bureau.
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This content has been developed independently of the sponsor, Novartis Pharma AG, who has had no editorial input into the content. Medthority received educational funding from the sponsor in order to help provide its healthcare professional members with access to the highest quality medical and scientific information, education and associated relevant content.
All opinions expressed in the ‘Food for Thought’ podcast series are those of the invited faculty. This content should not be taken as medical advice and is for informational purposes only. Please consult your regional clinical practice guidelines for clinical practice recommendations in your area.