Journal

Role of Platelets in Chronic Kidney Disease

Read time: 1 mins

Published: 16th Jun 2021

Author: Jain N, Corken A, Kumar A, Davis C, Ware J, Arthur J.

Source: Journal of the American Society of Nephrology

Availability: Pay for access, or by subscription

Ref.: J Am Soc Nephrol. 2021 Jun 17:ASN.2020121806.

DOI: 10.1681/ASN.2020121806

Role of Platelets in Chronic Kidney Disease

Platelet-dependent mechanisms for excessive clotting and bleeding in CKD remain undefined. Moreover, platelets’ contribution to inflammation, and specifically to CKD, are equally elusive. To date, descriptions of changes in the functional properties of circulating platelets during CKD have provided confusing interpretations. Experimental approaches that can advance our understanding of platelet dysfunction in CKD are needed, and studies that provide mechanistic insights into the dynamic relationships between thrombosis, bleeding, and inflammation associated with CKD will be essential to improve clinical management and outcomes for this vulnerable population. This article summarizes existing literature characterizing platelets in CKD and identifies areas that need further investigation.

Read abstract on library site Access full article

A blood draw being performed on the inside of a person's arm; testing for hyperkalaemia

Hyperkalemia

Disease information, latest news, and guidelines

A digital image of two human kidneys, stylised in blue and red

Chronic kidney disease

Expert insights on diagnosis and novel treatments

Digital close up of human kidney glomerulus and the Bowman Capsule

Glomerulonephritis

Unmet needs, latest news, and guideline updates

Featured Learning Zones

patient receiving dialysis, hospital image

Learning Zone

Chronic Kidney Disease Learning Zone

Chronic Kidney Disease (CKD) is a disease that can often lead to a need for haemodialysis and kidney transplantation. New CKD treatments are emerging which focus on delaying CKD disease progression and the need for transplantation.

You may be interested in...

Guideline

Reproductive health guidance for the cystic fibrosis community: a Cystic Fibrosis Foundation Position Paper

Developed by the Cystic Fibrosis Foundation, this position paper provides guidance on reproductive health care for individuals with cystic fibrosis. The recommendations address fertility, contraception, preconception counselling, pregnancy monitoring and the implications of CFTR modulator exposure during pregnancy and lactation.

Guideline

Addressing pain in people living with cystic fibrosis: Cystic fibrosis foundation evidence-informed guidelines

Developed by the Cystic Fibrosis Foundation, these evidence-informed recommendations address the assessment, management and communication of pain in people living with cystic fibrosis. The guidance promotes a multimodal approach to pain care, with consideration of age, underlying causes of pain, health equity and quality-of-life outcomes.

Guideline

Diagnosis and management of nephropathic cystinosis

International clinical practice recommendations developed using GRADE methodology provide evidence-based guidance on the diagnosis and lifelong management of nephropathic cystinosis. The recommendations address early diagnosis, cysteamine therapy, renal and extra-renal complications, and multidisciplinary care in children and adults to support long-term outcomes.