This site is intended for healthcare professionals
  • Home
  • /
  • Journals
  • /
  • Chronic kidney disease
  • /
  • Long-term efficacy of vildagliptin in patients wit...
Journal

Long-term efficacy of vildagliptin in patients with type 2 diabetes undergoing hemodialysis.

Read time: 1 mins
Published:25th Mar 2020
Author: Mera J, Okada E, Okuda M, Ota T, Sibata S, Uchida S.
Ref.:J Diabetes Metab Disord. 2015 Nov 5;14:83.
DOI:10.1186/s40200-015-0214-6.

Background: There are few studies evaluating long-term glycemic control using a dipeptidyl peptidase-4 inhibitor in type 2 diabetes patients with end-stage renal disease (ESRD). The aim of this study was to evaluate the safety and efficacy of vildagliptin therapy over 2 years in type 2 diabetes with ESRD.

Methods: Patients with ESRD resulting from type 2 diabetes requiring dialysis who had ≥20 % glycated albumin (GA) were enrolled. Vildagliptin 50 mg once daily was administered for 2 years. Changes in GA and dry weight were evaluated.

Results: In 32 patients (24 men and 8 women) aged 68.3 ± 1.9 years, vildagliptin 50 mg once daily was administered for 2 years, but the dose was increased to 50 mg twice daily in 15 patients. GA was significantly reduced by 2.6 ± 0.6 %, from 22.4 ± 0.6 % at baseline to 19.8 ± 0.4 % at 2 years. After 2 years of vildagliptin therapy, 15 (46.9 %) of 32 patients achieved a GA level of <20 %. Dry weight changed slightly, with an increase of 1.3 ± 0.8 kg at 2 years. No adverse drug reactions related to treatment with vildagliptin were seen.

Conclusions: Vildagliptin is a promising therapeutic option for safe, effective glycemic control in type 2 diabetic patients with ESRD.

Read abstract on library site