Deximune 100 mg soft capsules
4.1 Therapeutic indications
Solid Organ Transplantation
Prevention of graft rejection following solid organ transplantation.
Treatment of transplant rejection in patients previously receiving other immunosuppressive agents.
Bone Marrow Transplantation
Prevention of graft rejection following allogeneic bone marrow and stem cell transplantation.
Prevention or treatment of graft-versus-host disease (GVHD).
Treatment of sight-threatening intermediate or posterior uveitis of non-infectious aetiology in patients in whom conventional therapy has failed or caused unacceptable side effects.
Treatment of Behçet uveitis with repeated inflammatory attacks involving the retina in patients without neurological manifestations.
Deximune Capsules are indicated in patients with severe psoriasis in whom conventional therapy is ineffective or inappropriate.
Deximune Capsules are indicated in patients with severe atopic dermatitis when systemic therapy is required.
Deximune Capsules are indicated for the treatment of severe, active rheumatoid arthritis.
Steroid-dependent and steroid-resistant nephrotic syndrome due to primary glomerular diseases such as minimal change nephropathy, focal segmental glomerulosclerosis or membranous glomerulonephritis.
Deximune Capsules can be used to induce remissions and for maintenance remissions. It can also be used to maintain steroid-induced remission, allowing withdrawal of steroids.
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The Phase 2 primary objective is to evaluate achievement of persistent mixed chimerism and withdrawal of at least one immunosuppression drug for a minimum of 6 months with no episodes of biopsy-proven acute rejection or transplant kidney loss induced by cellular immunotherapy with MDR-102 in recipients of 1, 2, or 3 out of 6 human leukocyte antigen (HLA)-mismatched, living donor kidney transplants.
The purpose of this study is to investigate how efficiently the study medication imlifidase reduces the amount of donor specific antibodies (DSA) in comparison with plasma exchange (PE) therapy, in patients who have an active or chronic active antibody mediated rejection (AMR) after recently been kidney transplanted.
Combined and sequential liver-kidney transplantation (CLKT and SLKT) is a definitive treatment in children with end-stage organ failure. There are two major indications: - terminal insufficiency of both organs, or - need for transplanting new liver as a source of lacking enzyme or specific regulator of the immune system in a patient with renal failure.
Data on adult liver transplants performed in the US in 2017 are notable for (1) continued growth in numbers of new waitlist registrants (11,514) and of transplants performed (8,082); (2) continued increase in the transplant rate (51.5 per 100 waitlist-years)...
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Drugs appearing in this section are approved by UK Medicines & Healthcare Products Regulatory Agency (MHRA), & the European Medicines Agency (EMA).