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How important is a detailed clinical history when diagnosing IgE-mediated food allergies? Get to know the most recent recommendations for the diagnosis and management of food allergy as well as emerging treatments and diagnostics that may impact the future of food allergy management.
Optimising anti-TNF treatment using biosimilars
Biosimilars are uniquely placed to change clinical practice in the fields of gastroenterology, rheumatology, and dermatology. The adoption of biosimilars can improve patient access to the most appropriate treatment, at the optimum time, to ensure the best possible long-term disease outcomes.
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DBV Technologies announced that the FDA has lifted the partial clinical hold on the Company’s VITESSE (Viaskin Peanut Immunotherapy Trial to Evaluate Safety, Simplicity and Efficacy) Phase III clinical trial that will evaluate the modified Viaskin Peanut 250 microg patch (DBV712) in peanut-allergic children ages 4 to 7 years.
Kaléo, a privately held U.S. pharmaceutical company, announced that the FDA has approved its Naloxone Auto-injector 10 mg (naloxone hydrochloride injection) indicated for the emergency treatment of people 12 years of age and older where use of high-potency opioids such as fentanyl analogues as a chemical weapon, is suspected.
This work group report addresses the potential challenges of implementing an elimination diet for the management of EoE and provides instructions and tools for physicians, dietitians, and other allied health professionals to help guide them in planning elimination diets for both children and adults.
We aimed to clarify the use of PPIs in the evaluation and treatment of children and adults with suspected EoE to develop updated international consensus criteria for EoE diagnosis.
This document presents the official recommendations of the American Gastroenterological Association (AGA) and the Joint Task Force on Allergy-Immunology Practice Parameters (JTF) on the management of eosinophilic esophagitis.
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What is immunology?
Immunology is a branch of medicine and biology that investigates immunity, the immune system and immune cells in both healthy people and in immune-mediated diseases. There are several branches within immunology, including clinical immunology, diagnostic immunology and nutritional immunology. The immune system is the body’s natural defence against foreign substances on the skin, in body tissues and in bodily fluids1.
What are the components of the immune system?
The immune system is made up of the innate immune system and adaptive immune system. The innate immune system is the first-line, non-specific response to pathogens, such as bacteria and viruses. In the innate immune response, inflammatory cells, such as phagocytes and natural killer cells, destroy the pathogen. The adaptive immune system produces a slower response that targets the pathogen specifically using antibodies and cells like T lymphocytes and B lymphocytes. There are many different types of immune system disorders that can affect all the major body systems, including hypersensitivities and allergies, immune deficiencies and autoimmune diseases1.
What is immune hypersensitivity?
Hypersensitivities and allergies are responses that occur when the body responds inappropriately to antigens that are usually non-pathogenic, called allergens. Local atopic responses include asthma, contact dermatitis, urticaria and rhinitis. Other types of hypersensitivities include drug allergies and food allergies. A food allergy can occur in response to any of the 14 major allergens, including peanuts, milk and eggs. Severe food allergies can lead to anaphylaxis, a life-threatening condition. Immune cells involved in these hypersensitive immune responses are primarily leukocytes, such as T cells, monocytes, macrophages, eosinophils, basophils and mast cells2,3.
What are immunosuppressive disorders?
Immunosuppression, or immunodeficiency, is temporary or permanent weakening or suppression of the immune system. Immune suppression can arise from a variety of sources, including inherited or congenital diseases, also known as primary immunodeficiency disorder (PID), or primary immune deficiency diseases (PIDDs)4,5. Immunosuppression can also arise from acquired and/or chronic medical health conditions, such as heart disease, lung disease, diabetes, cancer and human immunodeficiency virus (HIV)6. Finally, immunosuppression can be caused by certain treatments such as chemotherapy, pregnancy, and short-lived infections like influenza. Immunocompromised patients are more likely to pick up opportunistic infections, like Covid-19, than people who are not immunocompromised7.
What are autoimmune disorders?
Autoimmune diseases, or autoimmunity, occur when adaptive immune cells that recognise host cells are unchecked, so the immune system attacks healthy host cells. Autoimmune diseases include psoriasis, psoriatic arthritis, rheumatoid arthritis, ulcerative colitis, crohn’s disease, systemic lupus erythematosus (lupus) and thyroid diseases. Autoimmune disorders are often associated with an inflammatory response which can cause acute inflammation or chronic inflammation8.
What is immunotherapy?
Immunotherapy is used to treat diseases by modulating the immune system, either by activation or suppression of the immune system. There has been much focus on immunotherapy for cancer treatment (cancer immunotherapy, or immuno-oncology) in recent years. Cancer immunotherapies include immune checkpoint inhibitors, T-cell transfer therapy, monoclonal antibodies (mAbs), treatment vaccines and immune system modulators9.
- Institute for Quality and Efficiency in Health Care (IQWiG) (2017). Abdominal aortic aneurysm: Overview. In: InformedHealth.Org [Internet]. Available at: https://www.ncbi.nlm.nih.gov/books/NBK441574/?report=reader - !po=10.0000 (Accessed May 2021).
- Valenta R, Hochwallner H, Linhart B, Pahr S. Food Allergies: The Basics. Gastroenterology. 2015;148:1120–1131.
- Mak TW, Saunders ME, Jett BD (2014). Immune Hypersensitivity. In: Primer to the Immune Response (Second Edition) [Internet]. Available at: https://www.sciencedirect.com/science/article/pii/B9780123852458000182 (Accessed May 2021).
- National Institute of Allergy and Infectious Diseases, 2014. Available at: https://www.niaid.nih.gov/research/immune-system-disorders (Accessed May 2021).
- McCusker C, Upton J, Warrington R. Primary immunodeficiency. 2018;14 (Suppl 2):141–152
- Alberta Health Services (2017). Available at: https://www.albertahealthservices.ca/assets/healthinfo/ipc/hi-ipc-immunocompromised-patients.pdf (Accessed May 2021).
- Centres for Disease Control and Prevention (2021). Available at: https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-with-medical-conditions.html (Accessed May 2021).
- Wang L, Wang F-S, Gershwin ME. Human autoimmune diseases: a comprehensive update. Intern. Med. 2015;278:369–395.
- National Cancer Institute (2019). Available at: https://www.cancer.gov/about-cancer/treatment/types/immunotherapy (Accessed May 2021).