Over the horizon: early stage trials for NASH
Another dozen or so drugs are in early stage trials. Most notably, VBL Therapeutics is currently testing lecinoxoids VB 201 and VB 703, antagonists for Toll-like receptors 2 and 4 (TLR-2 and TLR-4), which play a role in nonalcoholic fatty liver disease.
In an exploratory trial, VB 201 demonstrated significant reduction of vascular inflammation, suggesting that lecinoxoids can restrict liver inflammation and ameliorate liver fibrosis.
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