Bristol Myers Squibb shares research supporting correlation between New York Heart Association Functional Class (NYHA class) and mortality in obstructive hypertrophic cardiomyopathy.
“These data demonstrate the importance of assessing NYHA functional class in obstructive HCM patients,” said Neal Lakdawala, MD, cardiovascular medicine specialist at Brigham and Women's Hospital and lead author on the study. “We should determine the impact of therapies for obstructive HCM on patients' overall prognosis.”
Over a median follow-up of 3.9 years, the data show a 5% mortality rate in obstructive HCM patients initially classified as NYHA class I, 9% in class II, and 13% in class III/IV. Risks of all-cause mortality and the composite outcome of death or heart transplant increased with worse NYHA class at baseline (p<0.001). the study was conducted in partnership with the sarcomeric human cardiomyopathy registry (share) and presented at the heart failure society of america (hfsa) annual scientific meeting taking place from september 10 to 13, 2021.></0.001).>
“As approximately half a million people are affected by obstructive HCM worldwide, these data on the association between mortality and NYHA class in obstructive HCM patients are critical globally,” said Mitch Higashi, vice president of U.S. Health Economics and Outcomes Research, Bristol Myers Squibb. “The insight provided by these real-world data in identifying at-risk patients supports improved patient outcomes as well as healthcare efficiencies overall.”
About the Study : The study analyzed 2,495 obstructive HCM patients with a mean age of 47.6 years at diagnosis, 42% of whom were female. Patient characteristics varied across NYHA class. The Sarcomeric Human Cardiomyopathy Registry (SHaRe) enrolled patients from 10 HCM specialty centers worldwide. The study used data through March 2019, analyzing patients greater than 18 years old with obstructive HCM (left ventricular outflow tract (LVOT) peak gradient greater than 30 mmHg or septal reduction therapy) and documentation of NYHA class. Patients were followed from the date of index NYHA class assessment (first documentation of NYHA class I, II, III or IV) to last SHaRe visit or death. The risks of all-cause mortality and a composite endpoint of death and heart transplant were compared across index NYHA classes using log-rank tests.
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