Positive phase III POLO trial of Lynparza in germline BRCA-mutated metastatic pancreatic cancer. AstraZeneca + Merck Inc.
AstraZeneca and Merck Inc.,have announced positive results from the Phase III POLO trial of Lynparza ( olaparib) for gBRCAm metastatic pancreatic cancer. Results from the trial showed a statistically-significant and clinically-meaningful improvement in progression-free survival (PFS) with Lynparza (olaparib) vs. placebo. The safety and tolerability profile of Lynparza was consistent with previous trials.
POLO is a randomised, double-blinded, placebo-controlled trial exploring the efficacy of Lynparza tablets as 1st-line maintenance monotherapy in patients with germline BRCA-mutated (gBRCAm) metastatic adenocarcinoma of the pancreas (pancreatic cancer) whose disease has not progressed on platinum-based chemotherapy.
Jose Baselga, Executive Vice President, Research and Development, Oncology, said: �This is the first positive Phase III trial of any PARP inhibitor in germline BRCA-mutated metastatic pancreatic cancer, a devastating disease with critical unmet need. The results of POLO provide further evidence of the clinical benefit of Lynparza across a variety of BRCA-mutated tumour types. We will discuss these results with global health authorities as soon as possible.�
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