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Glembatumumab vedotin fails Phase II trial for triple negative breast cancer.- Celldex Therapeutics.

Read time: 1 mins
Last updated:18th Apr 2018
Published:18th Apr 2018
Source: Pharmawand

Celldex Therapeutics, Inc. reported that the Company's randomized, Phase IIb METRIC Study of glembatumumab vedotin compared to Xeloda (capecitabine) in patients with metastatic triple-negative breast cancers that overexpress gpNMB failed to meet its primary endpoint , progression-free survival (PFS) as assessed by an independent, central reading of patient scans (Hazard ratio = 0.95; median PFS: glembatumumab vedotin 2.9 months vs. Xeloda 2.8 months; p=0.76).

Comment: There was no significant advantage for glembatumumab vedotin in key secondary endpoints, including overall response rate, duration of response and overall survival.

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