Advances in vasomotor symptom treatments
Transcript: Linking oestradiol decline and depression
Dr Lisa Larkin
All transcripts are created from interview footage and directly reflect the content of the interview at the time. The content is that of the speaker and is not adjusted by Medthority.
Across the reproductive lifespan of women, we know that there are times when women are more vulnerable to mood disturbance. This is associated with times when women have changes in their hormonal milieu. We know that there are peak times such as the onset of menses, menarche, postpartum, when there's abrupt hormonal changes, and then through the perimenopause and menopause transition. These are times in a woman's life when she may be more susceptible to mood disturbance, and we know that this has something to do with changes.
It can be rate of changes in oestrogen or in absolute levels of oestrogen. And we know, not all women experience mood disturbance, but we know that women who, during their earlier years of life, have had mood disturbance as they transition in the perimenopause and menopause, they may be more susceptible. Again, it's not 100% of women, but we know that menopause and perimenopause is a time of mood instability, or it can be for many women. And this is something that we need to address.
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