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Responding to unmet needs for metastatic castration-resistant prostate cancer
mCRPC in focus

Expert opinions on mCRPC management

Last updated:4th Sep 2024
Published:28th Aug 2024

Topics in mCRPC management: Unmet needs, guidelines, clinical trials

Can investigational treatments address unmet needs in mCRPC?

Can investigational therapies enable mCRPC treatment in an “all-comer” patient population? Professor Axel Merseburger (University Hospital Schleswig-Holstein, Campus Lübeck, Germany) reflects on this and other possibilities. View transcript.

Barriers to uptake of clinical practice guidelines for mCRPC

Professor Merseburger discusses some key challenges in following clinical practice guideline recommendations for mCRPC management, and why guideline uptake remains low. View transcript.

Important considerations about patient populations in mCRPC trials

Dr Neeraj Agarwal (Huntsman Cancer Institute, University of Utah, USA) identifies an important caveat for patient populations in phase 3 first-line mCRPC trials, which he considers “the single most debated point” at conferences. View transcript.

Differences in clinical trial design for PARP inhibitors and novel hormonal therapies

Dr Agarwal describes similarities and differences in the design of the MAGNITUDE, TALAPRO-2, and PROpel mCRPC trials, noting all trials were “inherently different” and their similarities stop after three common features. View transcript.

Please answer the following questions before you read on (not mandatory). This helps us improve the educational design of our resources.

Please answer the following questions before you read on (not mandatory). This helps us improve the educational design of our resources.

1. According to the National Comprehensive Cancer Network, talazoparib plus enzalutamide is an option for patients with metastatic castration-resistant prostate cancer (mCRPC) and
2. Genomic changes leading to dysfunction of the cell-cycle regulators RB1 and/or cyclin-dependent kinases are present in up to what percentage of patients with mCRPC?
3. Why did the European Medicines Agency withdraw marketing authorization for sipuleucel-T in 2015?
4. A recent study revealed that some patients with mCRPC are willing to trade survival time for improvement in other outcomes. How much survival time are some patients prepared to trade for elimination of moderate nausea?
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