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Future breast cancer care: ESMO Breast Cancer 2024

Transcript: Transforming HER2-positive breast cancer care: The FeDeriCa study

Last updated:6th Jun 2024
Published:6th Jun 2024

Professor Diana Lüftner

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The interesting thing of the FeDeriCa trial is that it is now an update from the paper that was presented or written down in "The Lancet" in 2021, if I recall it correctly. And FeDeriCa is comparing in short terms IV pertuzumab and trastuzumab in the early setting, in the maintenance treatment, let me call it, for one year, versus subcutaneous administration with pertuzumab/trastuzumab. And the primary endpoint has been pharmacokinetic parameters that had shown that it is equivalent in terms of the serum concentrations that can be reached. What we've now seen is event-free survival data, so survival data, not only pharmacokinetic data, or PCR rates, but overall outcome data that were event equivalent. And this really supports the idea of using subcutaneous administration that is fast for patients and for healthcare personnel, and makes it so much easier. We have used pertuzumab/trastuzumab a lot in the pandemic, now where it was of a matter how long a patient is in the hospital, and how long he or she absorbs personnel that is necessary on other aspects because so many of us have been sick, or at least for some time. So it really supports the idea of saving time is good for the patient as well as for the hospital staff.

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