Chronic Spontaneous Urticaria Learning Zone
Transcript: Gülseren Tuncay on CSU phenotype studies
Gülseren Tuncay, MD
All transcripts are created from interview footage and directly reflect the content of the interview at the time. The content is that of the speakers and is not adjusted by Medthority.
Meeting was absolutely excellent collaboration and we learned many results after trials. In CSU especially, the co-existence of angioedema with wheals is known to increase disease burden. complicate disease control.
In the CSU study, were presented Charité data at EAACI, and it was observed that angioedema phenotype had a somewhat distinct clinical profile compared to the wheals, and wheals plus angioedema phenotypes. For example, the fact that metabolic comorbidities were more common in angioedema phenotype, with a prevalence of 50%. And similarly, the higher prevalence of atopic diseases in wheals phenotypes, wheals and wheals plus angioedema, and that these results support that the idea, these phenotypes may actually represent different endotypes.
I'm particularly focused on clinical and molecular differences between CSU phenotypes, and my research is ongoing in this direction as part of Charité team. And we are also working on a review for journal that specifically addresses the phenotypic differences in CSU up to now.
Although angioedema is generally told to resolve from stem cell mechanisms, stem cell-mediated mechanisms, the distinct clinical characteristics of these patients have also been highlighted in the literature. Therefore, it was particularly important to emphasise efficacy of ongoing phase studies, clinical trials, and available treatments, of course, across all CSU phenotypes. And even though patients with angioedema may present with different clinical features compared to the other phenotypes, it's highly valuable that ongoing clinical trials are investigating efficacy across all phenotypes.
It's a new treatment approach to see in this clinical trial, these phenotypic differences.
Updates in your area
of interest
of interest
Articles your peers
are looking at
are looking at
Bookmarks
saved
saved
Days to your
next event
next event
This content has been developed independently by Medthority who previously received educational funding from Novartis in order to help provide its healthcare professional members with access to the highest quality medical and scientific information, education and associated relevant content.