This site is intended for healthcare professionals
  • Home
  • /
  • Journals
  • /
  • Psoriasis
  • /
  • Psoriasis and other complex trait dermatoses: from...
Journal

Psoriasis and other complex trait dermatoses: from Loci to functional pathways

Read time: 1 mins
Published:1st Mar 2012
Author: Capon F, Burden AD, Trembath RC, Barker JN.
Availability: Free full text
Ref.:J Invest Dermatol. 2012 Mar;132(3 Pt 2):915-22.
DOI:10.1038/jid.2011.395
Psoriasis and other complex trait dermatoses: from Loci to functional pathways


Driven by advances in molecular genetic technologies and statistical analysis methodologies, there have been huge strides taken in dissecting the complex genetic basis of many inflammatory dermatoses. One example is psoriasis, for which application of classical linkage analysis and genome-wide association investigation has identified genetic loci of major and minor effect. Although most loci independently have modest genetic effects, they identify important biological pathways potentially relevant to disease pathogenesis and therapeutic intervention. In the case of psoriasis, these appear to involve the epidermal barrier, NF-κB mechanisms, and T helper type 17 adaptive immune responses. The advent of next-generation sequencing methods will permit a more detailed and complete map of disease genetic architecture, a key step in developing personalized medicine strategies in the clinical management of the complex inflammatory dermatoses.


Read abstract on library site    Access full article