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Clinical meaningfulness of complete skin clearance in psoriasis

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Published:30th Jun 2016

Author: Strober B, Papp KA, Lebwohl M, Reich K, Paul C, Blauvelt A et al.

Source: Journal of the American Academy of Dermatology

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Ref.:J Am Acad Dermatol. 2016 Jul;75(1):77-82.e7.

DOI:10.1016/j.jaad.2016.03.026

Clinical meaningfulness of complete skin clearance in psoriasis

Background: New psoriasis therapies have increased the ability to achieve skin clearance. However, insufficient evidence exists on the impact of total skin clearance from the patient perspective.

Objective: We sought to determine if complete skin clearance is clinically meaningful compared with treatment responses without clearance.

Methods: Pooled data from 3 phase-III trials were used to compare results for patients with complete skin clearance (Psoriasis Area and Severity Index [PASI] 100 or static Physician Global Assessment score 0) with patients without complete skin clearance (PASI 75 to <100 or static Physician Global Assessment score 1) based on Psoriasis Symptom Inventory and Dermatology Life Quality Index.

Results: Percentages of patients with Psoriasis Symptom Inventory score 0 were 45% for those achieving PASI 100 and 8% for PASI 75 to <100 (P < .001). Respective percentages with Dermatology Life Quality Index score 0/1 were 80% and 55% (P < .001). PASI 100 resulted in incremental improvement over PASI 90 to <100 (incremental differences of 28% for Psoriasis Symptom Inventory score 0 and 18% for Dermatology Life Quality Index score 0). Similar results were observed for static Physician Global Assessment scores 0 versus 1.

Conclusions: Complete skin clearance represents a clinically meaningful end point and outcome for patients, reflected in experiences of no psoriasis symptoms and no impairment on health-related quality of life.

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