Journal

Anti-interleukin-17 treatment of psoriasis

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Published:31st Jul 2016

Author: Jinna S, Strober B.

Source: Journal of Dermatological Treatment

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Ref.:J Dermatolog Treat. 2016 Aug;27(4):311-5.

DOI:10.3109/09546634.2015.1115816

Anti-interleukin-17 treatment of psoriasis

Psoriasis is a chronic, immune-mediated, inflammatory dermatosis, affecting 2-3% of the US population. While first-generation cytokine antagonists targeting tumor necrosis factor alpha (TNF-α)-dependent pathways have produced favorable responses in the treatment of psoriasis, higher levels of efficacy in a greater proportion of patients have been shown in trials with antibodies targeting interleukin (IL)-17A and the IL-17 receptor subunit. This examines the role of IL-17 inhibitors in the treatment of plaque psoriasis. The efficacy and safety results from the phase-3 trials with monoclonal antibodies targeting IL-17RA (brodalumab) and IL-17A (ixekizumab and secukinumab) validate IL-17 as a highly effective therapeutic target for the treatment of plaque psoriasis.

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