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Nasal instillation of probiotic extracts inhibits experimental allergic rhinitis.

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Published:3rd Sep 2019
Author: Zeng XH, Yang G, Liu JQ, Geng XR, Cheng BH, Liu ZQ et al.
Source: Immunotherapy
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Ref.:Immunotherapy. 2019.
DOI:10.2217/imt-2019-0119
Nasal instillation of probiotic extracts inhibits experimental allergic rhinitis


Aim:
Allergic rhinitis (AR) is a common disease. The therapeutic efficacy of AR needs to be improved. This study aims to evaluate the effects of local administration of probiotic extracts on inhibiting experimental AR.

Methods: Epithelial cells (ECs) were primed by exposing to Clostridium butyricum extracts (CBe) in the culture to upregulate the expression of IL-10. A mouse AR model was developed to assess the therapeutic potential of CBe in AR.

Results: CBe markedly induced the expression of IL-10 in ECs. Co-culture of naive B cells with CBe-primed ECs significantly increased IL-10 expression in the B cells (iB10 cells). The iB10 cells showed immune suppressive function in suppressing effector CD4+ T-cell proliferation. Treatment with nasal drops containing CBe efficiently inhibited experimental AR in mice.

Conclusion: Local administration of CBe can efficiently inhibit experimental AR.

 

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