This site is intended for healthcare professionals
  • Home
  • /
  • Journals
  • /
  • Other liver diseases
  • /
  • Hyperfibrinolysis in liver disease.
Journal

Hyperfibrinolysis in liver disease.

Read time: 1 mins
Published:1st Feb 2009
Author: Ferro D, Celestini A, Violi F.
Availability: Pay for access, or by subscription
Ref.:Clin Liver Dis. 2009;13(1):21-31.
DOI:10.1016/j.cld.2008.09.008

The incidence of hyperfibrinolysis in patients with cirrhosis is still debated. The reasons for this uncertainty probably lie in the lack of appropriate laboratory tests for its evaluation. There is a relative consensus, however, that hyperfibrinolysis can complicate the clinical course of liver cirrhosis, especially in cases of moderate to severe liver failure.

Hyperfibrinolysis correlates positively with the severity of underlying liver disease, and low-grade systemic fibrinolysis is found in 30% to 46% of patients who have end-stage liver disease. Accelerated intravascular coagulation with secondary hyperfibrinolysis has been reported in patients who have liver failure. Hyperfibrinolysis may delay primary hemostasis, thereby aggravating variceal bleeding and facilitating recurrence.

 

Read abstract on library site

Access full article