This site is intended for healthcare professionals
  • Home
  • /
  • Journals
  • /
  • Leukaemia
  • /
  • Treatment of adult acute lymphoblastic leukemia wi...
Journal

Treatment of adult acute lymphoblastic leukemia with inotuzumab ozogamicin.

Read time: 1 mins
Published:1st Oct 2017
Author: Paul S, Rausch CR, Kantarjian H, Jabbour EJ.
Source: Future Oncology
Availability: Pay for access, or by subscription
Ref.:Future Oncol. 2017;13(25):2233-2242.
DOI:10.2217/fon-2017-0233

Treatment of adult acute lymphoblastic leukemia (ALL) has largely relied on cytotoxic chemotherapy agents borrowed from successful treatment regimens of pediatric ALL. However, the high cure rates seen in pediatric ALL have not been replicated in adults. In recent years, the development of monoclonal antibodies targeting cell surface antigens, such as CD19 and CD20, have significantly improved outcomes when used alone or in combination with cytotoxic chemotherapy. With these novel agents come challenges in managing adverse events, understanding mechanisms of resistance and determining their optimal place in therapy alongside conventional chemotherapy and allogeneic stem cell transplant. Herein we discuss the above challenges with the next addition to the armamentarium of antileukemic agents, inotuzumab ozogamicin, an antibody-drug conjugate against CD22.

 

Read abstract on library site

Access full article