This site is intended for healthcare professionals
  • Home
  • /
  • Journals
  • /
  • Hypertension complicating pregnancy\childbirth
  • /
  • Angiogenic factors: potential to change clinical p...

Angiogenic factors: potential to change clinical practice in pre-eclampsia?

Read time: 1 mins
Published:29th Nov 2017
Author: Cerdeira AS, Agrawal S, Staff AC, Redman CW, Vatish M.
Availability: Free full text
Ref.:BJOG. 2017.

Pre-eclampsia is a complex disease with significant maternal and fetal morbidity and mortality. Its syndromic nature makes diagnosis and management difficult. The field is rapidly evolving with the definition of pre-eclampsia being challenged by some organisations, with proteinuria no longer being essential in the presence of other features. In the last decade, angiogenic factors, in particular soluble fms-like tyrosine kinase 1 (sFlt-1), have emerged as important molecules in the pathogenesis of pre-eclampsia. Here we review the most recent evidence regarding the potential of these factors as biomarkers and therapeutic targets for pre-eclampsia.

Tweetable abstract: A review of angiogenic factors, sFlt-1 and PlGF, in the diagnosis, prediction and management of pre-eclampsia.


Read abstract on library site

Access full article