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Incidence of hidradenitis suppurativa in the United States: A sex- and age-adjusted population analysis

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Published:9th Mar 2017

Author: Garg A, Lavian J, Lin G, Strunk A, Alloo A.

Source: Journal of the American Academy of Dermatology

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Ref.:J Am Acad Dermatol. 2017b Mar 9. pii: S0190-9622(17)30163-9.

DOI:10.1016/j.jaad.2017.02.005.

Incidence of hidradenitis suppurativa in the United States: A sex- and age-adjusted population analysis

Background: The true incidence of hidradenitis suppurativa (HS) is unknown.

Objective: To determine standardized incidence estimates for HS in the United States.

Methods: We used a retrospective cohort analysis, including incident HS cases identified using electronic health records data for a demographically heterogeneous population-based sample of >48 million unique patients across all 4 census regions. We calculated standardized 1- and 10-year cumulative incidences for the overall population and for sex-, age-, and race-specific groups.

Results: There were 5410 new HS diagnoses over a 1-year period, with an incidence of 11.4 (95% confidence interval [CI], 11.1-11.8) cases per 100,000 population. One-year incidence in women was 16.1 (95% CI, 15.5-16.6) per 100,000, more than twice that of men [6.8 (95% CI, 6.5-7.2) per 100,000; P < .0001]. Age group-specific incidence was highest among patients 18 to 29 years of age [22.0 (95% CI, 21.0-23.2) per 100,000]. Incidence among African Americans [30.6 (95% CI, 29.1-32.2) per 100,000] was >2.5 times that of whites [11.7 (95% CI, 11.3-12.2) per 100,000; P < .0001]. The average annual overall incidence over 10 years was 8.6 (95% CI, 8.6-8.7) per 100,000 population.

Limitations: The use of deidentified claims prevented validation for a larger case subset.

Conclusion: HS incidence has increased over the past decade and disproportionately involves women, young adults, and African Americans.

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