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Journal

IgE in the pathophysiology and therapy of food allergy

Read time: 1 mins
Published:28th Feb 2021
Author: Michelet M, Balbino B, Guilleminault L, Reber LL.
Availability: Free full text
Ref.:Eur J Immunol. 2021 Mar;51(3):531-543.
DOI:10.1002/eji.202048833
IgE in the pathophysiology and therapy of food allergy


Food allergy is becoming a major public health issue, with no regulatory approved therapy to date. Food allergy symptoms range from skin rash and gastrointestinal symptoms to anaphylaxis, a potentially fatal systemic allergic shock reaction. IgE antibodies are thought to contribute importantly to key features of food allergy and anaphylaxis, and measurement of allergen-specific IgE is fundamental in diagnosing food allergy. This review will discuss recent advances in the regulation of IgE production and IgE repertoires in food allergy. We will describe the current understanding of the role of IgE and its high-affinity receptor FcεRI in food allergy and anaphylaxis, by reviewing insights gained from analyses of mouse models. Finally, we will review data derived from clinical studies of the effect of anti-IgE therapeutic monoclonal antibodies (mAbs) in food allergy, and recent insight on the efficiency and mechanisms through which these mAbs block IgE effector functions.


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