This site is intended for healthcare professionals
  • Home
  • /
  • Journals
  • /
  • Chronic obstructive pulmonary disease (COPD) and b...
  • /
  • The pathology of small airways disease in COPD: hi...

The pathology of small airways disease in COPD: historical aspects and future directions.

Read time: 1 mins
Published:4th Mar 2019
Author: Higham A, Quinn AM, Cançado JED, Singh D.
Availability: Free full text
Ref.:Respir Res. 2019;20(1):49.

Small airways disease (SAD) is a cardinal feature of chronic obstructive pulmonary disease (COPD) first recognized in the nineteenth century. The diverse histopathological features associated with SAD underpin the heterogeneous nature of COPD. Our understanding of the key molecular mechanisms which drive the pathological changes are not complete. In this article we will provide a historical overview of key histopathological studies which have helped shape our understanding of SAD and discuss the hallmark features of airway remodelling, mucous plugging and inflammation.

We focus on the relationship between SAD and emphysema, SAD in the early stages of COPD, and the mechanisms which cause SAD progression, including bacterial colonization and exacerbations. We discuss the need to specifically target SAD to attenuate the progression of COPD.


Read abstract on library site

Access full article