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Clinical trial

Fibrinogen Concentrate in Isolated Traumatic Brain Injury

Read time: 3 mins
Last updated:22nd Oct 2018
Identifier: NCT03304899

Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropriate firmness. In severe traumatic brain injury(TBI) patients, plasma fibrinogen concentrations decrease earlier and more frequently than other coagulation factors,predicting massive bleeding and death.

The purpose of this study is to try early injection of fibrinogen concentrate in severe isolated traumatic brain injury and investigation the effect of it on post bleeding and complications.

Study Type: Interventional  (Clinical Trial)
Estimated Enrollment: 50 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Prevention
Official Title: Early Fibrinogen Concentrate in Isolated Traumatic Brain Injury and the Effect on Post Bleeding & Complications
Actual Study Start Date: October 23, 2018
Estimated Primary Completion Date: December 21, 2019
Estimated Study Completion Date: January 21, 2020

- Experimental:
Case group
- Active Comparator: Control group

Category Value
Date last updated at source 2019-02-27
Study type(s) Interventional
Expected enrolment 50
Study start date 2018-10-23
Estimated primary completion date 2019-12-21

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