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Clinical trial

Acute Neurological ICU Sedation Trial (ANIST)

Read time: 2 mins
Last updated:31st Mar 2005
Identifier: NCT00390871
Dexmedetomidine (Precedex, Hospira) is a "super" selective alpha2-agonist - 8-10x more avid binding to alpha2 receptors than clonidine - and may have particularly favorable characteristics as a continuous i.v. infusion sedative for critically ill neuroscience patients. Its combination of anxiolysis, analgesia, without undue lethargy may make it an ideal agent where frequent neurological examinations are important (12). Unclear, however, is whether Precedex is superior to current common i.v. sedation protocols, and if there are any undue concerns of this agent on cerebral physiology and cortical stimulation.


Category Value
Date last updated at source 2013-04-11
Study type(s) Interventional
Expected enrolment 60
Study start date 2005-04-01
Estimated primary completion date 2008-06-01

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