Treatment of Post-Operative Sinonasal Polyposis With Topical Furosemide
Treatment of Post-Operative Sinonasal Polyposis With Topical Furosemide
Prior studies have suggested that topical furosemide may reduce the recurrence of sinonasal polyposis following sinus surgery. This project aims to further investigate that claim through a blinded randomized controlled clinical trial following patients who undergo functional sinus surgery for chronic rhinosinusitis with sinonasal polyposis by randomly assigning participants to receive topical furosemide versus placebo nasal spray for 2 months post operatively. Outcomes would be compared at 6 months through endoscopic grading scores using Lund Kennedy and Meltzer scores as well as Sino-Nasal Outcome Test (SNOT-22) scores to measure the rate and degree of recurrence and impact on symptoms in the treatment group versus placebo.
Study Type: Interventional (Clinical Trial)
Estimated Enrollment: 100 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Treatment of Post-Operative Sinonasal Polyposis With Topical Furosemide
Actual Study Start Date: December 1, 2017
Estimated Primary Completion Date: November 2020
Estimated Study Completion Date: June 2021
Arm:
- Experimental: Furosemide
- Placebo Comparator: Placebo
| Category | Value |
|---|---|
| Study type(s) | Interventional |
| Estimated enrolment | 100 |
| Actual Study start date | 01 December 2017 |
| Estimated Study Completion Date | 01 June 2021 |