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Shionogi acquires rights to olorofim from F2G Ltd., for invasive fungal infections in Europe and Asia.

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Published:18th May 2022

Shionogi & Co, Ltd. and F2G Ltd. announced that they have entered a strategic collaboration to develop and commercialize the new antifungal agent olorofim for invasive fungal infections in Europe and Asia.

Olorofim is a novel oral antifungal therapy developed by F2G to treat invasive aspergillosis (IA) and other rare mold infections.

Olorofim works through a unique mechanism of action, different from existing classes of antifungals, exerting fungicidal activity through inhibition of the pyrimidine synthesis pathway. Olorofim represents the first novel antifungal class developed in the past 20 years and is the only antifungal medication to be awarded a Breakthrough Therapy Designation (BTD) for multiple indications by the FDA.

Under the terms of the agreement, Shionogi will conduct the clinical trials and subsequent registration and commercialization of olorofim for IA in Europe and Asia. Shionogi will make an upfront payment to F2G of $100 million and share development costs in global studies. F2G will also be eligible to receive additional regulatory and commercial milestones of up to $380 million, as well as double-digit royalties on net sales.

F2G is currently preparing for a global PIII study, which will enroll 225 invasive aspergillosis patients resistant to azoles or who cannot use these therapies. The two partners will now jointly pursue the olorofim program including this PIII study.

Condition: Infectious Diseases/ Invasive Aspergillosis
Type: drug

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