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  • Phase III PANTHER trial of TAK 924 + Vidaza failed...

Phase III PANTHER trial of TAK 924 + Vidaza failed to meet primary endpoint in myelodysplastic syndromes.- Takeda

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Published:3rd Sep 2021
Takeda Pharmaceutical announced that the Phase III PANTHER (Pevonedistat-3001) study of TAK 924 + Vidaza (pevonedistat plus azacitidine) did not achieve pre-defined statistical significance for the primary endpoint of event-free survival (EFS). The trial evaluated whether the combination of pevonedistat plus azacitidine as first-line treatment for patients with higher-risk myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and low-blast acute myeloid leukemia (AML) improved EFS versus azacitidine alone.

An event in the trial is defined as death or transformation to AML in participants with higher-risk MDS or CMML, whichever occurs first, and death in participants with AML. Full data results will be submitted for presentation at an upcoming medical congress. Investigators have been informed of the outcome so they can discuss the potential impact with study participants. Takeda will work with investigators who will determine the most appropriate action for each individual patient enrolled in the study.

Condition: Myelodysplastic Syndromes
Type: drug

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