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Pivotal phase III SIERRA trial data showing 100% bone marrow transplant engraftment in patients treated with Iomab-B presented at the 2021 virtual SNMMI conference.- Actinium Pharmaceuticals.

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Published:16th Jun 2021
Actinium Pharmaceuticals, Inc. highlighted data from its pivotal Phase III SIERRA trial for Iomab-B in an oral presentation at the 2021 Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting, which is to be held virtually from June 11th – 14th.

The SIERRA trial is the only randomized Phase III trial to offer potentially curative BMT as an option for patients with active, relapsed or refractory acute myeloid leukemia (r/r AML) age 55 and above, a patient population not considered eligible for BMT with standard non-targeted conditioning regimens. SNMMI Presentation Title: "Relationship of Marrow Radiation Dose and Timing of Engraftment for Targeted Radioimmunotherapy with Anti-CD45 Iodine (131I) Apamistamab [Iomab-B] in Patients with Active Relapsed or Refractory Acute Myeloid Leukemia" : Presenter: Susan Passalaqua, MD, Banner MD Anderson Cancer Center. SNMMI Presentation Highlights : i. 100% BMT and engraftment rate for patients receiving a therapeutic dose of Iomab-B compared to 18% of patients receiving physician's choice of salvage therapy on the control arm. ii.79% of all patients enrolled on SIERRA were able to proceed to BMT despite being a patient population not considered eligible for BMT with standard approaches. iii. Iomab-B delivers high amounts of targeted radiation to the bone marrow with minimal impact on other organs resulting in lower rates and severity of adverse events.

Condition: AML/Bone Marrow Transplant
Type: drug

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