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KEYNOTE-564 evaluating Keytruda is the first phase III study to show positive results for adjuvant immunotherapy in renal cell carcinoma.- Merck Inc.,

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Published:5th Jun 2021
Merck Inc., announced first-time results from the pivotal Phase III KEYNOTE-564 trial evaluating Keytruda, Merck’s anti-PD-1 therapy, for the potential adjuvant treatment of patients with renal cell carcinoma (RCC) at intermediate-high or high risk of recurrence following nephrectomy (surgical removal of a kidney) or following nephrectomy and resection of metastatic lesions. After a median follow-up of 24.1 months (14.9-41.5), Keytruda demonstrated a statistically significant and clinically meaningful reduction in the risk of disease recurrence or death by 32% compared to placebo (HR=0.68 [95% CI, 0.53–0.87]; p=0.0010).

Additionally, a favorable trend in overall survival (OS) was observed with a 46% reduction in the risk of death with Keytruda as compared to placebo (HR=0.54 [95% CI, 0.30–0.96]; p=0.0164). As previously announced, the trial will continue to evaluate OS, a key secondary endpoint. The late-breaking results will be presented in the Plenary session of the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting (Abstract #LBA5) on Sunday, June 6, 2021 . As announced, data spanning more than 20 types of cancer will be presented from Merck’s oncology research program at ASCO. A compendium of presentations and posters of Merck-led studies will be posted by Merck on Friday, June 4 at 9 a.m. ET. Follow Merck on Twitter via @Merck and keep up to date with ASCO news and updates by using the hashtag #ASCO21.

Condition: Renal Cell Carcinoma
Type: drug

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