This site is intended for healthcare professionals
  • Home
  • /
  • News
  • /
  • 2021
  • /
  • 12
  • /
  • CHMP opinion positive for Lorviqua as first-line t...

CHMP opinion positive for Lorviqua as first-line treatment for ALK-positive advanced NSCLC.- Pfizer Inc.

Read time: 1 mins
Published:19th Dec 2021
Pfizer Inc. announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion recommending Lorviqua (lorlatinib, available in the U.S. under the brand name Lorbrena), for marketing authorization as a first-line treatment of adults with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC).

The CHMP’s opinion will now be verified by the European Commission (EC) with a decision expected in the coming months. The application for the first-line use of Lorviqua was based on the results of the pivotal Phase III CROWN trial, in which Lorviqua reduced the risk of disease progression or death by 72% compared to Xalkori(crizotinib). In patients with measurable brain metastases, 82% of patients in the Lorviqua arm experienced an intracranial response (71% experiencing an intracranial complete response), compared to 23% of Xalkori patients.

Condition: NSCLC/ ALK+
Type: drug

Learning Zones

The Learning Zones are an educational resource for healthcare professionals that provide medical information on the epidemiology, pathophysiology and burden of disease, as well as diagnostic techniques and treatment regimens.