EMPEROR-Preserved phase III trial of Jardiance shows efficacy in heart failure.- Eli Lilly + Boehringer
As previously reported, EMPEROR-Preserved showed that Jardiance significantly reduced the risk for the composite primary endpoint of cardiovascular death or hospitalization for heart failure in adults with heart failure with LVEF over 40% compared with placebo. Jardiance also significantly reduced the risk of first and recurrent hospitalizations for heart failure and slowed kidney function decline. Over half (53.5%) of adults in EMPEROR-Preserved had chronic kidney disease (defined as eGFR below 60 mL/min/1.73 m2 or UACR above 300 mg/g) at trial entry, and 9.7% had severe kidney impairment (eGFR below 30 mL/min/1.73 m2).
The new prespecified sub-analysis of EMPEROR-Preserved demonstrated that the benefits seen in the overall population were consistent in adults with and without chronic kidney disease. Jardiance consistently improved cardiovascular outcomes and slowed kidney function decline across the full range of kidney function down to an eGFR of 20 mL/min/1.73 m2. Jardiance was well tolerated regardless of the level of baseline kidney function. The results were presented at the American Society of Nephrology Kidney Week 2021.