Lilly's OVERCOME study reveals nearly 80% of people reported improvement in their migraine since starting a CGRP monoclonal antibody for preventive treatment.

Nearly 80% of people taking calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) for the preventive treatment of migraine reported their migraine as "better" overall since starting their medication, according to a web-based population survey. Close to two-thirds (62.6%) said they also used an additional recommended migraine preventive medication with their CGRP mAbs. Eli Lilly and Company announced the results, which are among the first real-world, population-based, patient-reported outcomes from people using CGRP mAbs as a migraine preventive treatment and suggest these novel medications lead to improvement in how patients perceive their migraine. The latest findings from Lilly's OVERCOME study are being presented virtually at the 18th Migraine Trust International Symposium (MTIS 2020). "It is very encouraging that nearly 4 out of 5 people in the survey taking a CGRP monoclonal antibody felt better and reported their migraine had improved," said Sait Ashina, M.D., Department of Neurology and Department of Anesthesia, Critical Care and Pain Medicine, and Harvard Medical School, Beth Israel Deaconess Medical Center, and scientific advisor to the OVERCOME study. "It is also notable that the OVERCOME survey reported the clinically meaningful distinction between individuals who reported no change in their migraine with those who said their migraine worsened. This distinction can enhance conversations between the healthcare provider and the patient regarding treatment expectations when considering the use of these novel migraine preventive medications." Patient's Assessment of Their Migraine After Taking a CGRP mAb for Preventive Treatment : Of the 586 people who reported using a CGRP mAb for the preventive treatment of migraine in the past three months, 79.2% reported perception of their migraine as "better," 11.3% indicated "no change" and 9.6% said it was "worse." These findings were relatively consistent across groups: 80.3% (0-3 headache days per month), 80.8% (4-7 headache days per month), 79.8% (8-14 headache days per month) and 74.6% ( greater than 15 headache days per month). Data was obtained from participants in Q4 2019 and represented 2.8% of the 20,782 participants in the U.S. OVERCOME 2019 survey. Patients' perception of improvement in their migraine were measured using the Patient Global Impression of Improvement (PGI-I) scale. PGI-I responses were categorized as better, no change, or worse. Use of Additional Recommended Migraine Preventive Medication : Among respondents who used a CGRP mAb in the previous 3 months, 62.6% used an additional recommended migraine preventive medication. This finding is consistent with the 2018 position statement of the American Headache Society (AHS) on integrating new migraine treatments into clinical practice and with patients' existing treatment plans. Use of an additional migraine preventive medication was generally higher for patients with more frequent migraine headache days per month: 56.8% (0-3 headache days per month), 64.6% (4-7 headache days per month), 70.9% (8-14 headache days per month) and 70.2% (?15 headache days per month). Recommended preventive medications for migraine were defined by the guidelines of the American Academy of Neurology (AAN) as well as the AHS position statement, and included topiramate, divalproex sodium/valproate sodium, metoprolol, propranolol, timolol, atenolol, nadolol, amitriptyline, nortriptyline, venlafaxine, duloxetine and onabotulinumtoxinA. About the OVERCOME Study : The Observational Survey of the Epidemiology, Treatment and Care of Migraine (OVERCOME) study aims to further understand the unmet needs of those with migraine by assessing the burden of migraine experienced by people living with the disease, identify barriers to the appropriate treatment of migraine, and assess how the introduction of novel treatment options may influence delivery of migraine care and outcomes. OVERCOME is a prospective, web-based patient survey and will enroll 100,000 individuals with migraine from regions across the globe. U.S. OVERCOME will enroll more than 60,000 individuals with migraine using a prospective, multi-cohort, longitudinal study design to follow U.S. population samples with migraine for two years following their enrollment. In addition, nearly 40,000 individuals with migraine from other regions across the globe will complete a cross-sectional survey. In parallel, OVERCOME will also include 24,000 people who did not have migraine, providing a unique perspective about how migraine is perceived by those who do not have the disease. OVERCOME began enrollment in Q4 2018.