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Data from phase III trial of Sublocade in opioid use disorder published in Journal of Addiction Medicine

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Last updated:11th Mar 2019
Published:8th Mar 2019
Source: Pharmawand

Indivior announced the publication of patient-centered outcome endpoints (health status, physical and mental health, medication satisfaction, employment, health insurance status and healthcare resource utilization) of Sublocade (buprenorphine extended-release) injection for subcutaneous use in opioid use disorder by the Journal of Addiction Medicine. These measures were collected during the 24-week, Phase III, randomized, placebo-controlled study assessing the drug's efficacy, safety and tolerability.

The results showed that participants receiving Sublocade versus placebo experienced significant changes from baseline on the EQ-5D-5L index (300/300mg: difference=0.0636) and visual analog scale (300/300mg: difference=5.9, 300/100mg: difference=7.7), and on the SF-36v2 physical component summary score (300/300mg: difference=3.8; 300/100mg: difference=3.2). Treatment satisfaction was significantly higher at the end of study for participants receiving Sublocade 300/300mg and 300/100mg than placebo. Employment increased by 10.8% with Sublocade 300/300mg and 10.0% with 300/100mg but decreased by 12.6% with placebo. Participants receiving Sublocade compared with placebo had significantly fewer hospital days per person-year observed.

See: "Patient-centered Outcomes in Participants of a Buprenorphine Monthly Depot (BUP-XR) Double-blind, Placebo-controlled, Multicenter, Phase 3 Study." Ling W et al. J Addict Med. March 2019 DOI: http://dx.doi.org/10.1097/ADM.0000000000000517

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