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Genentech/Roche cancels CREED-1 and d CREED 2 Phase III trials of crenezumab for Alzheimer's Disease

Read time: 1 mins
Last updated:31st Jan 2019
Published:31st Jan 2019
Source: Pharmawand

Genentech, a member of the Roche Group, announced the decision to discontinue CREAD 1 and CREAD 2 (BN29552 and BN29553) Phase III studies of the investigational anti-beta-amyloid molecule crenezumab in people with early (prodromal to mild) sporadic Alzheimer´┐Żs disease (AD).

The decision was based on the results of a pre-planned interim analysis assessing the safety and efficacy of crenezumab conducted by the Independent Data Monitoring Committee, which indicated that crenezumab was unlike . No safety signals for crenezumab were observed in this analysis, and the overall safety profile was similar to that seen in previous trials. Data from the CREAD 1 and 2 studies will be shared with the scientific community at an upcoming medical congress. Findings from the trials will inform future research programs, approaches and clinical trial designs.

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