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EMPA-REG OUTCOME trial of Jardiance in T2D + CV published in Circulation.- Boehringer + Eli Lilly.

Read time: 1 mins
Last updated:11th Oct 2018
Published:11th Oct 2018
Source: Pharmawand

Novel results based on data from the landmark EMPA-REG OUTCOME trial were published in the journal Circulation which suggest that treatment with Jardiance (empagliflozin), from Boehringer Ingelheim and Eli Lilly, positively impacts life expectancy in adults with type 2 diabetes and established cardiovascular disease. Using actuarial methods, and assuming that the demonstrated beneficial effects of Jardiance remain consistent with long-term use, Jardiance was estimated to extend life expectancy by 1 to 4.5 years on average, depending on age, when compared with placebo.

This analysis suggests that treatment with Jardiance could add years of life. In an analysis of data from 7,020 people included in the EMPA-REG OUTCOME trial, estimated life expectancy increased across all ages when adults were treated with Jardiance as compared to those treated with placebo. Specifically, estimated mean survival in people aged 45 years was 32.1 years with Jardiance versus 27.6 years with placebo, resulting in a mean survival difference of 4.5 years. In people aged 50, 60, 70 and 80 years old, the mean survival difference with Jardiance compared to placebo was an additional 3.1 years, 2.5 years, 2 years and 1 year, respectively.

See: "Long-Term Benefit of Empagliflozin on Life Expectancy in Patients With Type 2 Diabetes Mellitus and Established Cardiovascular Disease: Survival Estimates From the EMPA-REG OUTCOME Trial," Brian Claggett et al. Circulation 8 Oct 2018; 138:1599�1601.

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