Drug news
NICE does not recommend Ninlaro (ixazomib) combination + lenalidomide + dexamethasone as a treatment for multiple myeloma.-Takeda
The National Institute for Health and Care Excellence (NICE), in a draft recommendation, has rejected Ninlaro (ixazomib) combination with lenalidomide and dexamethasone from Takeda as a cost effective treatment for Multiple Myeloma in patients who have had one or more treatments. NICE noted that the pivotal trial for the drug was still ongoing and available data are limited and it is unclear if the combination will prolong life. NICE considered that the progression free survival (PFS) benefits of the combination appear to reduce with longer follow up. Takeda responded that the TOURMALINE-MMI trial demonstrated that the combination increased PFS by around six months with less toxicity than competing therapies.