Rova-T (rovalpituzumab tesirine) results for treatment of Small Cell Lung Cancer- AbbVie
AbbVie announced that treatment with rovalpituzumab tesirine (Rova-T), a delta-like protein 3 (DLL3)-targeted antibody-drug conjugate (ADC), demonstrated a confirmed overall response rate (ORR) of 39 percent and clinical benefit rate (stable disease or better) of 89 percent in patients with recurrent or refractory small cell lung cancer (SCLC), identified with high expression of DLL3.
Rova-T demonstrated a one-year overall survival (OS) rate of 32 percent in the recurrent/refractory second- and third-line patient population. These new data were presented at the 52nd Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago and featured in the "Best of ASCO" program, which presents scientific and educational highlights from the meeting.
Comment: If data hold up in subsequent trials Rova-T could become the first targeted drug ever approved for small cell lung cancer.
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