Updated survival results of EMILIA study for T-DM1 for metastatic Breast Cancer

Genentech has announced updated survival results from the Phase III EMILIA study, which showed that people with previously treated HER2-positive metastatic Breast Cancer (mBC) survived significantly longer (overall survival, a co-primary endpoint) when treated with trastuzumab emtansine (T-DM1) compared to those who received the combination of lapatinib and Xeloda (capecitabine). Results showed the risk of death was reduced by 32 percent for people who received trastuzumab emtansine compared to those who received lapatinib plus Xeloda (HR=0.68, p=0.0006). People in the study treated with trastuzumab emtansine survived a median of 5.8 months longer than those who received lapatinib and Xeloda (median overall survival: 30.9 months vs. 25.1 months). No new safety signals were observed and adverse events (AEs) were consistent with those seen in previous studies, with fewer people who received trastuzumab emtansine experiencing Grade 3 or higher (severe) AEs than those who received lapatinib plus Xeloda (40.8 percent vs. 57.0 percent).