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Exelixis reports results for XL 184 in Thyroid Cancer

Read time: 1 mins
Last updated:8th Jun 2012
Published:8th Jun 2012
Source: Pharmawand
Top line results were reported by Exelixis for XL 184 (cabozantinib) for the primary endpoint in the 330-patient Phase III EXAM study in patients with locally advanced or metastatic medullary Thyroid Cancer which showed a 7.2-month improvement in progression-free survival (PFS) with cabozantinib compared to placebo - 11.2 months of PFS versus four months. n terms of secondary endpoints, the overall response rate was 28% in the cabozantinib arm and 0% in the placebo arm. The Kaplan Meier estimate for PFS at one year was 47.3% with cabozantinib and only 7.2% for patients on placebo. Overall survival data are not yet mature.

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