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Histopathology of liver steatosis, or fatty liver. Light micrograph, photo under microscope
IFN-Gamma in Hyperinflammation: Key Insights

Accredited secondary HLH/MAS masterclass

Last updated: 7th Oct 2025
Published: 7th Oct 2025

Accredited masterclass: Fabrizio de Benedetti on diagnosing and treating secondary HLH/MAS

To earn 1 CME credit, watch the full session and then complete the knowledge assessment and evaluation form.

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“Early recognition and timely intervention are critical to improving outcomes in HLH/MAS.” Watch this EBAC-accredited masterclass, presented by Fabrizio de Benedetti, to deepen your understanding of the diagnosis, biomarkers, and treatment strategies for secondary hemophagocytic lymphohistiocytosis / macrophage activation syndrome (HLH/MAS). This three-part series offers expert insights into managing this often underdiagnosed, rapidly progressive, and life-threatening hyperinflammatory syndrome.

Watch now to:

  • Recognize the urgency of HLH/MAS and its potential for rapid clinical progression
  • Apply biomarker-driven stratification to assess disease severity and monitor treatment response
  • Assess how targeted therapies, including IL-1 inhibitors and IFN-γ blockade, are reshaping the treatment landscape for both pediatric and adult patients


How much do you know about HLH/MAS? Answer these six questions to find out. We’ll ask you the questions again after you’ve watched the masterclass to see what you recall.

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Meet the expert

Fabrizio de Benedetti, MD, PhD, circular imageFabrizio de Benedetti, MD, PhD

Fabrizio de Benedetti is a pediatric rheumatologist who serves as Director of the Division of Rheumatology and Head of the Laboratory of Immuno-Rheumatology at Ospedale Pediatrico Bambino Gesù in Rome, Italy. He is also Professor of Pediatric Rheumatology at the Universities Tor Vergata and La Sapienza.

De Benedetti’s work focuses on both clinical and translational research in pediatric rheumatology. He has been the principal investigator for several pivotal phase 2/3 clinical trials of novel targeted therapies in pediatric rheumatic diseases, including Still’s disease, polyarticular juvenile idiopathic arthritis, macrophage activation syndrome, familial Mediterranean fever, mevalonate kinase deficiency, and tumor necrosis factor receptor–associated periodic syndrome.

Disclosures: Abbott, Bristol Myers Squibb, Novartis, Novimmune, Pfizer, Roche, and Sobi.

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