Interpreting HRR results with confidence
Episode 5. Alicia Morgans and Bertrand Tombal discuss the nuanced interpretation of HRR genetic reports in mPC, including the clinical ambiguity of non-BRCA mutations such as ATM and CHEK2, the importance of variant classification, and zygosity in predicting treatment response. Tombal shares practical strategies, from confirmatory testing to leveraging curated databases to assess rare variants, and emphasizes oncogenetic vigilance as combination therapies become more prevalent. “You don’t expect everybody to just look at the report and say, ‘That’s a good one.’ No, you have to dig in and do some preliminary work,” he advises, underscoring the importance of context and multidisciplinary collaboration in clinical decision-making. View transcript.
Chapters
00:32 How to interpret HRR genetic reports
04:06 Challenges in HRR result reading
09:07 Navigating unclear HRR results
10:16 HRR testing in combination therapy
13:19 Multidisciplinary decision-making
16:32 Tips for interpreting HRR data
Meet the guest speaker
Bertrand Tombal, MD, PhD
Bertrand Tombal is a Full Professor and Chair of Urology at Université catholique de Louvain and Cliniques universitaires Saint-Luc in Brussels, Belguim. A past president of the European Organisation for Research and Treatment of Cancer (EORTC), he focuses on advanced prostate cancer and has contributed extensively to research and publications in genitourinary oncology.
Disclosures: Advisor or investigator for Amgen, Astellas, AstraZeneca, Accord Healthcare, Bayer, Myovant, Johnson & Johnson and MSD.
Developed by EPG Health. This content has been developed independently of the sponsor, Pfizer, which has had no editorial input into the content. EPG Health received funding from the sponsor to help provide healthcare professional members with access to the highest quality medical and scientific information, education and associated relevant content. This content is intended for healthcare professionals only.
of interest
are looking at
saved
next event