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Low magnification microscopic image of a desmoid tumor in purple with a pink background.

Desmoid tumors: Insights from DGHO 2025

Supported by SpringWorks Therapeutics
Last updated: 12th Nov 2025
Published: 4th Nov 2025

Management of desmoid tumors

What are the latest advances in the care of people with desmoid tumors? Bernd Kasper (Mannheim University Medical Centre, Germany) and Maya Niethard (University Hospital Regensburg, Germany) discussed their perspectives at Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie (DGHO) 2025 in Cologne, Germany. Watch updates on:

  • Clinical presentation and diagnostic assessment
  • Understanding the patient’s point of view
  • Advances in the desmoid tumor treatment landscape
  • The surgical management of desmoid tumors

Content is available with German or English captions. Die Inhalte sind mit deutschen oder englischen Untertiteln verfügbar.

How much do you know about the management of desmoid tumors? Take this quiz to find out.

1. What is the diagnostic assessment pathway when assessing someone who is suspected of having a desmoid tumor?
2. If you have a patient with a newly diagnosed desmoid tumor, what treatment would you typically start with?
3. What is a key side effect of the latest approved medication class, gamma secretase inhibitors?

Unmet needs and diagnostic assessment

What is the most significant unmet need in the management of desmoid tumors? Kasper gives his view, and describes the clinical presentation and techniques for diagnostic assessment of this rare disease. View transcript. Hier das Transkript anzeigen.

After watching this video, are you more confident in the clinical presentation and diagnostic assessment of desmoid tumors in your clinical practice?

Patient perspective and communication

Kasper considers the lived experience of people with desmoid tumors, and the importance of communicating both benefits and risks of the latest treatments. View transcript. Hier das Transkript anzeigen.

After watching this video, are you more confident in understanding the lived experience of people with desmoid tumors in your clinical practice?

Advances in the treatment landscape

How is the treatment landscape of desmoid tumors evolving? Kasper reviews the available treatments for desmoid tumors, the paradigm shift from surgical approaches, and what he expects over the next 5 years. View transcript. Hier das Transkript anzeigen..

After watching this video, are you more confident in selecting and evaluating treatment options for desmoid tumors in your clinical practice?

A surgeon’s perspective on management

What role does surgery play in the management of desmoid tumors? Niethard discusses the place of surgeons in the multidisciplinary team and the key considerations when deciding whether surgery should be recommended to a patient. View transcript. Hier das Transkript anzeigen.

After watching this video, are you more confident in the role of surgery and its place in the multidisciplinary care of desmoid tumors in your clinical practice?

Meet the experts

 

Bernd Kasper, MD, PhDBernd Kasper, MD, PhD

Bernd Kasper works at the Sarcoma Unit of the Mannheim Cancer Center (MCC) at the Mannheim University Medical Center, University of Heidelberg, Germany. Kasper has dedicated his professional life to patient care and research in soft tissue sarcomas, desmoid-type fibromatosis, and gastrointestinal stromal tumors. His clinical practice focuses exclusively on these disease entities. He is head of the study center of the German Interdisciplinary Sarcoma Group (GISG) and is active in national and international study groups (AIO, EORTC).

Disclosures: Advisory roles or expert testimonies for Ayala, Bayer, Boehringer Ingelheim, Deciphera, Parabilis Medicines, PharmaMar, and SpringWorks Therapeutics. Honoraria from Bayer and PharmaMar. Funding for scientific research from Cogent Biosciences, Immunome, PharmaMar, and SpringWorks Therapeutics.

Maya Niethard, MD Maya Niethard, MD

Maya Niethard is Head of the Sarcoma Center and the Department of Orthopedic Oncology at the University Hospital Regensburg, Germany.

Disclosures: No disclosures provided at the time of publication.

 

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Development of this education content has been supported by a grant/funding from SpringWorks Therapeutics. The content has been independently developed by EPG Health with no input or influence from SpringWorks Therapeutics.

Copyright © 2011 Michael Bonert, MD, FRCPC. Image licensed under CC BY-SA 3.0.