Alpha-1 Antitrypsin Deficiency: Bridging Care
AATD liver care: EASL 2025 summary
Key takeaways from the EASL 2025 symposium on AATD
This infographic summarizes the main topics discussed during a symposium chaired by Rohit Loomba, focused on the liver care journey in alpha-1 antitrypsin deficiency (AATD). Whether you attended the session or are catching up, this overview shares key updates on detection, care pathways, and emerging therapies.
Clinical highlights:
- Early detection and family screening
- AATD often presents asymptomatically until advanced liver disease. Early genotype-based screening (especially Pi*ZZ) is critical for identifying high-risk individuals and initiating timely interventions
- Multidisciplinary liver–lung care
- Joint clinics and collaborative care between hepatologists and pulmonologists improve outcomes. Annual assessments using FibroScan and spirometry are recommended
- Non-invasive fibrosis assessment
- Tools like APRI (aspartate aminotransferase to platelet ratio index) and transient elastography support risk stratification without biopsy
- Emerging therapies
- siRNA: Phase 3 trials show promise in reducing liver globule burden
- RNA editing: Reversible transcript-level therapy in early-phase trials
- CRISPR gene correction: Preclinical studies targeting misfolded protein pathways
- Folding correctors: Aim to restore protein secretion and reduce endoplasmic reticulum stress
We should definitely try and work together better so that we can be offering a patient-centered service.
Alice Turner, MBChB
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Developed by EPG Health. This content has been developed independently of the sponsor, Takeda, which has had no editorial input into the content. EPG Health received funding from the sponsor to help provide healthcare professional members with access to the highest quality medical and scientific information, education and associated relevant content. This content is intended for healthcare professionals only.