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Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations

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Published:27th Feb 2019
Author: Abdullah MI, Junit SM, Ng KL, Jayapalan JJ, Karikalan B, Hashim OH.
Availability: Free full text
Ref.:Int J Med Sci. 2019 Feb 28;16(3):450-460.
DOI:10.7150/ijms.29935
Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations


Papillary thyroid cancer (PTC) is the most prevalent form of malignancy among all cancers of the thyroid. It is also one of the few cancers with a rapidly increasing incidence. PTC is usually contained within the thyroid gland and generally biologically indolent. Prognosis of the cancer is excellent, with less than 2% mortality at 5 years. However, more than 25% of patients with PTC developed a recurrence during a long term follow-up. The present article provides an updated condensed overview of PTC, which focuses mainly on the molecular alterations involved and recent biomarker investigations.


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